Magic Mushrooms And Ketamine: Psychedelic Therapy For Bipolar

Magic Mushrooms and Ketamine: Psychedelic Therapy For Bipolar

In the evolving landscape of mental health treatment, the use of psychedelics has garnered significant attention in recent years.

As a Clinical Therapist, I’ve observed the growing interest in psychedelic substances, particularly magic mushrooms, and ketamine, as potential treatment options for various mood disorders, including bipolar depression.

Historical Context

The use of psychedelics for therapeutic purposes isn’t a new concept. In fact, many cultures have utilized hallucinogenic mushrooms and other substances for spiritual and healing rituals for centuries.

Long before modern clinical trials and scientific investigations, indigenous tribes in various parts of the world recognized the transformative power of these natural substances.

In the Amazon rainforest, for instance, the brew known as Ayahuasca, a combination of plants containing the psychedelic compound DMT, has been used by shamans to facilitate spiritual awakenings and healing ceremonies.

Similarly, in ancient Mesoamerican cultures, psilocybin-containing mushrooms, often referred to as “teonanácatl” or “flesh of the gods,” played a pivotal role in religious and shamanic rituals.

These ceremonies were believed to connect the participants with the divine, provide insights into the mysteries of existence, and promote emotional and psychological healing.

In other parts of the world, substances like peyote, a cactus containing the psychedelic mescaline, were integral to the spiritual practices of Native American tribes.

These rituals were not only about individual healing but also about community bonding and maintaining a harmonious relationship with nature and the cosmos.

However, with the advent of the 20th century and the global spread of Western medicine, the use of psychedelics in therapeutic settings became a topic of scientific curiosity.

The 1950s and 60s saw a surge in research exploring the potential of substances like LSD (lysergic acid diethylamide) and psilocybin for treating a range of mental health disorders, from anxiety to addiction.

Unfortunately, due to socio-political reasons and the association of these substances with counter-culture movements, research into their therapeutic potential was halted for several decades.

Today, as we witness a renaissance in psychedelic research, it’s essential to acknowledge and respect the deep historical roots of these substances.

Their use in ancient rituals and traditions offers valuable insights into their potential not just as therapeutic agents, but also as tools for personal and collective transformation.

What Are Magic Mushrooms And Ketamine?

Magic mushrooms, scientifically known as psilocybin mushrooms, have been used in various cultures for their hallucinogenic properties.

These fungi contain the active compound psilocybin, which, when ingested, is converted into psilocin in the human body. This compound interacts with the brain’s serotonin receptors, leading to altered perceptions, emotions, and thoughts.

There are over 180 known species of psilocybin mushrooms, and they can be found in various parts of the world, from North and South America to Europe and Asia.

Historically, these mushrooms were consumed during religious and shamanic rituals, allowing participants to connect with higher realms, gain spiritual insights, or embark on introspective journeys.

In modern times, aside from their recreational use, there’s growing interest in the potential therapeutic applications of psilocybin, especially in the realms of mental health and personal development.

On the other hand, ketamine is a synthetic compound, initially developed in the 1960s as a replacement for PCP (phencyclidine) as an anesthetic. Due to its rapid onset and short duration of action, it became widely used in surgical procedures, especially in veterinary medicine.

Read more about Ketamine Assisted Therapy.

However, beyond its anesthetic properties, ketamine has shown promise in treating treatment-resistant depression.

Unlike traditional antidepressants, which often take weeks to show effects, ketamine can provide relief from depressive symptoms within hours. It operates differently from most antidepressants, targeting the NMDA receptors in the brain.

This action is believed to promote the growth of new neural connections, potentially helping to repair and restore brain areas impacted by depression.

Recent findings from clinical research have indicated that even low doses of ketamine, administered under controlled conditions, can have long-lasting beneficial effects for individuals with major depressive disorder, bipolar depression, and even post-traumatic stress disorder (PTSD).

Given its rapid action and effectiveness, ketamine infusion clinics have started to emerge in various parts of the United States and other countries, offering hope to those who haven’t found relief from conventional treatment methods.

The Science Behind Psychedelic Therapy

Psychedelics, including psilocybin from magic mushrooms and ketamine, interact with serotonin receptors in the brain. This interaction can lead to alterations in mood, perception, and cognition, which can be therapeutic for some individuals with mood disorders.

Serotonin, often referred to as the “feel-good” neurotransmitter, plays a crucial role in regulating mood, appetite, sleep, and overall well-being.

When psychedelics like psilocybin enter the system, they bind to specific serotonin receptors, particularly the 5-HT2A receptor. This binding results in a cascade of neural events, leading to increased neural plasticity, enhanced connectivity between different brain regions, and altered patterns of brain activity.

One of the most notable effects of this interaction is the temporary dissolution of the default mode network (DMN) – a network of brain regions that is active when the mind is at rest and not focused on the external world.

The DMN is associated with self-referential thoughts, ego, and our sense of identity. When the activity of the DMN is reduced, individuals often report experiences of ego dissolution, a feeling of oneness with the universe, and profound insights into their lives and behaviors.

Such experiences can lead to lasting positive changes in personality traits, attitudes, and behaviors.

Ketamine, while also interacting with the serotonin system, primarily acts on the NMDA receptors, which are involved in learning, memory, and neuroplasticity. By blocking these receptors, ketamine promotes the release of a neurotransmitter called glutamate.

This surge in glutamate activates AMPA receptors, leading to increased production of brain-derived neurotrophic factor (BDNF). BDNF plays a pivotal role in the growth and survival of neurons, enhancing neural connections and pathways.

This process is believed to help “reset” certain neural circuits that are dysfunctional in mood disorders, offering rapid relief from depressive symptoms.

Furthermore, the altered state of consciousness induced by these substances provides a unique therapeutic window. Within this window, individuals can confront and process traumatic memories, reevaluate negative thought patterns, and gain insights into their behaviors and life choices.

When combined with psychotherapy, this introspective state can facilitate deep emotional processing and healing.

In recent years, modern clinical trials have begun to shed light on the potential of psychedelic-assisted therapy.

Preliminary results suggest that, when administered in controlled settings and combined with psychotherapy, psychedelics can offer significant relief from various mental health conditions, including depression, anxiety, PTSD, and substance use disorders.

As research continues to evolve, the scientific community is becoming increasingly optimistic about the potential of these substances to revolutionize the field of mental health treatment.

Benefits of Psychedelic Therapy For Bipolar

Clinical studies have indicated that psilocybin therapy can alleviate depressive symptoms in individuals with major depressive disorder. Similarly, ketamine infusions have shown positive results in improving the quality of life for those with treatment-resistant depression.

Bipolar disorder, characterized by alternating episodes of mania and depression, can be a challenging condition to manage. Traditional treatments, such as mood stabilizers and antipsychotic medications, are the primary line of defense.

However, not everyone responds favorably to these treatments, and some may continue to experience debilitating symptoms. This is where the potential of psychedelic therapy comes into play.

Psilocybin Therapy

Recent research has delved into the potential benefits of psilocybin, the active compound in magic mushrooms, for various mental health conditions.

For bipolar patients, especially those predominantly struggling with depressive episodes:

  1. Enhanced Emotional Connectivity: Psilocybin has been shown to increase emotional connectivity, allowing individuals to process emotions more deeply. This can be particularly beneficial for those with bipolar depression, who often feel emotionally numb or detached.
  2. Long-lasting Relief: Some studies suggest that a single dose of psilocybin can provide relief from depressive symptoms for weeks or even months. This prolonged effect can offer a respite for individuals who otherwise experience frequent mood swings.
  3. Improved Self-awareness: The introspective nature of the psychedelic experience can help individuals gain insights into their behaviors, thought patterns, and triggers, empowering them to manage their condition more effectively.

Ketamine Infusions

Ketamine, on the other hand, offers a different set of benefits:

  1. Rapid Symptom Relief: Unlike most antidepressants that take weeks to show effects, ketamine can provide relief in a matter of hours. This rapid action can be life-saving for those in the midst of a severe depressive episode.
  2. Neuroplasticity Boost: Ketamine promotes the growth of new neural connections, potentially helping to repair brain areas impacted by chronic stress and depression.
  3. Reduction in Suicidal Ideation: Some studies have shown that ketamine can significantly reduce suicidal thoughts, a symptom commonly associated with bipolar depression.
  4. Enhanced Psychotherapy: The altered state of consciousness induced by ketamine can enhance the therapeutic process, allowing individuals to confront and process traumatic or painful memories more effectively.

MDMA Assisted Therapy

MDMA, commonly known as “Ecstasy” or “Molly”, has been gaining attention in the realm of psychedelic therapy, especially for its potential to treat post-traumatic stress disorder (PTSD) and enhance the psychotherapeutic process.

For individuals with bipolar disorder, MDMA-assisted therapy can offer:

  • Emotional Release: MDMA is known to induce feelings of emotional warmth and empathy. This can help bipolar patients, especially those who have suppressed traumatic memories, to confront and process these emotions in a therapeutic setting.
  • Strengthened Therapeutic Alliance: The empathogenic effects of MDMA can enhance the bond between the therapist and the patient, making the therapeutic process more effective and trustful.
  • Reduced Fear Response: MDMA reduces the activity in the amygdala, the part of the brain responsible for fear. This can be beneficial for bipolar patients who may have trauma-associated memories, allowing them to address these memories without being overwhelmed by fear or anxiety.
  • Potential for Long-term Improvement: Preliminary studies have shown that when combined with psychotherapy, MDMA can lead to long-term improvements in symptoms of PTSD and related disorders. This suggests potential benefits for bipolar patients, especially those with co-morbid PTSD or trauma.

It’s essential to note that while MDMA shows promise, it’s currently completing Phase 3 clinical trials in preparation for FDA New Drug Applications.

MDMA-assisted therapy is already approved by the Food and Drug Administration (FDA) on an Expanded Access (“compassionate use”) basis for PTSD, with full approval projected for 2024.

Risks And Considerations

Like all treatment options, psychedelic therapy comes with potential risks. Adverse effects can range from mild to severe, and it’s crucial for individuals to be aware of these risks, especially if they have a history of manic or hypomanic episodes.

Physical Risks

  1. Cardiovascular Effects: Some psychedelics can lead to increased heart rate and blood pressure. While these effects are generally temporary, they can be concerning for individuals with pre-existing heart conditions.
  2. Nausea and Vomiting: Especially common with the ingestion of certain psychedelic substances, such as magic mushrooms. While not typically severe, it can be uncomfortable for the user.
  3. Overstimulation: Some individuals might experience heightened sensitivity to light, sound, and touch, which can be overwhelming.

Psychological Risks

  1. Exacerbation of Pre-existing Conditions: There’s a potential that psychedelic substances can exacerbate symptoms in individuals with certain mental health conditions, such as schizophrenia or severe anxiety disorders.
  2. Challenging Experiences: Often referred to as “bad trips,” these can include feelings of paranoia, extreme confusion, and fear. While these experiences can be therapeutically beneficial in a controlled setting, they can be traumatic without proper guidance and support.
  3. Potential for Mania: Especially pertinent to individuals with bipolar disorder, there’s a risk that psychedelic substances can trigger manic or hypomanic episodes. This underscores the importance of thorough screening and evaluation before undergoing psychedelic therapy.

Long-term Considerations

  1. Hallucinogen Persisting Perception Disorder (HPPD): A rare condition where individuals experience recurring flashbacks to their psychedelic experiences. These can manifest as visual disturbances or altered perceptions.
  2. Dependence and Misuse: While classic psychedelics like psilocybin are not considered addictive, there’s potential for misuse, especially if individuals seek out the substances outside of therapeutic settings.
  3. Integration Challenges: Post-session, individuals might face challenges integrating their psychedelic experiences into their daily life. Without proper support, this can lead to feelings of alienation or confusion.

Setting And Guidance

The environment in which psychedelic therapy takes place plays a crucial role in determining the outcome of the session. A safe, comfortable, and controlled setting, combined with the guidance of trained professionals, can significantly mitigate many of the risks associated with psychedelic use.

In conclusion, while psychedelic therapy offers promising benefits, it’s not without its risks. It’s essential for individuals and therapists alike to approach this treatment option with caution, thorough knowledge, and respect for the power of these substances.

Proper screening, preparation, and post-session integration support are vital components of a safe and effective psychedelic therapy experience.

The Therapeutic Process

A typical psychedelic therapy session is conducted in a controlled environment under the guidance of trained professionals.

The therapist plays a pivotal role in ensuring the safety and well-being of the patient throughout the psychedelic experience.

Pre-Session Preparation

  1. Screening and Assessment: Before undergoing psychedelic therapy, patients undergo a thorough screening process. This includes a detailed medical and psychological evaluation to determine suitability and to identify any potential contraindications.
  2. Setting Expectations: The therapist will discuss the potential effects of the psychedelic substance, what the patient might experience, and address any concerns or fears. This helps in building trust and setting a positive intention for the session.
  3. Mindset Preparation: The patient’s mindset plays a significant role in shaping the psychedelic experience. Therapists often employ techniques like meditation, guided imagery, or breathwork to help patients enter the session with a calm and open mind.

During the Session

  1. Safe Environment: The therapy room is usually designed to be calming and comfortable. Soft lighting, relaxing music, and comfortable seating or lying areas are common features.
  2. Guided Experience: As the effects of the psychedelic substance take hold, the therapist remains present, offering guidance, reassurance, and support. They may encourage the patient to explore particular emotions, memories, or sensations that arise.
  3. Monitoring Physical Well-being: Throughout the session, the therapist, or a medical professional, may monitor vital signs like heart rate and blood pressure to ensure the patient’s physical safety.

Post-Session Integration

  1. Debriefing: Once the effects of the psychedelic have worn off, the therapist and patient engage in a debriefing session. This allows the patient to process, articulate, and make sense of their experience.
  2. Integration Techniques: The insights gained during a psychedelic session can be profound. Therapists may use various techniques, such as journaling, art therapy, or group discussions, to help patients integrate these insights into their daily lives.
  3. Follow-up Sessions: Ongoing therapy sessions, without the use of psychedelics, can be beneficial. These sessions provide an opportunity to delve deeper into the themes and insights from the psychedelic experience and apply them to real-life challenges.

Comparing Traditional And Psychedelic Therapies

While traditional treatments like mood stabilizers and selective serotonin reuptake inhibitors (SSRIs) remain the cornerstone of bipolar disorder management, the potential of psychedelic-assisted therapy is becoming increasingly evident through modern clinical trials.

Traditional Therapies

  1. Mechanism of Action: Traditional treatments, such as SSRIs, work by increasing the levels of serotonin in the brain, thereby improving mood and reducing depressive symptoms. Mood stabilizers, on the other hand, help regulate mood swings and prevent episodes of mania and depression.
  2. Duration of Effect: These medications often require daily intake and may take weeks or even months to show noticeable effects. The benefits last as long as the medication is taken, and discontinuation can lead to a relapse of symptoms.
  3. Side Effects: Common side effects of SSRIs include weight gain, sexual dysfunction, and sleep disturbances. Mood stabilizers might cause dizziness, tremors, and gastrointestinal issues.
  4. Accessibility: Traditional treatments are widely available and are often the first line of treatment recommended by psychiatrists and primary care providers.

Psychedelic-Assisted Therapy

  1. Mechanism of Action: Psychedelics like psilocybin interact with serotonin receptors, leading to altered brain connectivity and function. This can result in profound introspective experiences that can be therapeutic when guided properly.
  2. Duration of Effect: Unlike traditional treatments, psychedelic-assisted therapy often involves one or a few sessions, with the effects lasting for extended periods. Some patients report improvements in mood and well-being for weeks or even months after a single session.
  3. Side Effects: Potential side effects include nausea, increased heart rate, and challenging psychological experiences. However, in a controlled setting with trained professionals, the risks are minimized.
  4. Accessibility: While the promise of psychedelic-assisted therapy is significant, it’s not yet widely available. It’s primarily offered in research settings or specialized clinics, and regulatory approval is still in progress in many regions.

Legal And Ethical Considerations

The legal status of substances like magic mushrooms varies across regions. It’s essential for both therapists and patients to be aware of the legal implications of using these substances for therapeutic purposes.

Legal Status

  1. Magic Mushrooms: In many countries, psilocybin, the active compound in magic mushrooms, is classified as a Schedule I drug, meaning it’s considered to have a high potential for abuse and no accepted medical use. However, some regions, like the state of Oregon in the USA, have recently decriminalized its use, and others allow it for religious or therapeutic purposes under specific conditions.
  2. Ketamine: While ketamine is a legal prescription medication used primarily as an anesthetic, its use outside of this context, especially for recreational purposes, can be illegal in many jurisdictions.
  3. Research Exemptions: In some regions, researchers can obtain exemptions or licenses to study the therapeutic potential of these substances. These exemptions allow them to administer psychedelics to study participants in a controlled environment.

Ethical Considerations

  1. Informed Consent: Given the powerful effects of psychedelics, it’s crucial for therapists to ensure that patients fully understand the potential risks and benefits. Patients should be provided with comprehensive information and give their informed consent before undergoing any psychedelic-assisted therapy.
  2. Safety and Well-being: Therapists have an ethical responsibility to ensure the safety and well-being of their patients. This includes proper screening to determine suitability, creating a safe and supportive environment during sessions, and providing post-session integration support.
  3. Avoiding Coercion: It’s essential to ensure that patients are choosing psychedelic therapy of their own free will and are not being coerced or unduly influenced.
  4. Confidentiality: As with all medical treatments, therapists must maintain the confidentiality of their patients, especially given the stigma and legal implications associated with psychedelic use.
  5. Training and Competence: Only trained and competent professionals should administer psychedelic-assisted therapy. This ensures that patients receive the highest standard of care and that any challenges or adverse effects during sessions are managed appropriately.


Here are some books on Psychedelic Therapy that you may find interesting.

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Laurie Newcomb, MA, LPC, NCC, CCTP

Licensed Professional Counselor, MA, LPC, NCC, CCTP My goal for each therapy session is to respect the client, allow them to be heard, appreciate where they are coming from, and help guide them through their struggles or issues. My approach to therapy is to utilize an integrative approach with clients. What this means is that I utilize different approaches for different people, as we are not all alike. Whether you're suffering from depression, anxiety, trauma, or any other kind of challenge, you want a therapist you feel comfortable with and who can help you bring about change. I have experience working with substance abuse, anxiety, depression, trauma, and life transitions. I am personally passionate about assisting clients who have endured trauma in their life. I am certified in trauma therapy and continue to work with clients with substance abuse.